Structure of PDB 4oel Chain A

Receptor sequence
>4oelA (length=281) Species: 9606 (Homo sapiens) [Search protein sequence]
DTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTA
YDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTG
WVHDVLGRNWACFTGKKVLHLPTSWDWRNVHGINFVSPVRNQASCGSCYS
FASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKY
AQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALM
KLELVHHGPMAVAFEVYDDFLHYKKGIYHHT
3D structure
PDB4oel The amino-acid substituents of dipeptide substrates of cathepsin C can determine the rate-limiting steps of catalysis.
ChainA
Resolution1.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Q228 C234
Catalytic site (residue number reindexed from 1) Q142 C148
Enzyme Commision number 3.4.14.1: dipeptidyl-peptidase I.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SER A D1 C234 G276 G277 F278 D1 C148 G190 G191 F192 PDBbind-CN: -logKd/Ki=7.00,Ki=0.1uM
BS02 TYR A G232 C234 E275 G146 C148 E189 PDBbind-CN: -logKd/Ki=7.00,Ki=0.1uM
Gene Ontology
Molecular Function
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:4oel, PDBe:4oel, PDBj:4oel
PDBsum4oel
PubMed22928782
UniProtP53634|CATC_HUMAN Dipeptidyl peptidase 1 (Gene Name=CTSC)

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