Structure of PDB 4oed Chain A

Receptor sequence
>4oedA (length=242) Species: 9606 (Homo sapiens) [Search protein sequence]
QPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWA
KALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSAMLYFAPDLV
FNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVD
GLKNQKFFDELRMNYIKELDRIIASCSRRFYQLTKLLDSVQPIARELHQF
TFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHT
3D structure
PDB4oed Identification of a new androgen receptor (AR) co-regulator BUD31 and related peptides to suppress wild-type and mutated AR-mediated prostate cancer growth via peptide screening and X-ray structure analysis.
ChainA
Resolution2.79 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A V716 K720 Q733 M734 I737 Q738 E893 M894 E897 V47 K51 Q64 M65 I68 Q69 E217 M218 E221
BS02 DHT A L701 L704 N705 Q711 M742 M749 F764 T877 L32 L35 N36 Q42 M73 M80 F95 T201 BindingDB: IC50=>10000nM,EC50=6nM,Ki=0.2nM
External links
PDB RCSB:4oed, PDBe:4oed, PDBj:4oed
PDBsum4oed
PubMed25091737
UniProtP10275|ANDR_HUMAN Androgen receptor (Gene Name=AR)

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