Structure of PDB 4ocv Chain A

Receptor sequence
>4ocvA (length=355) Species: 391904 (Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM 20088) [Search protein sequence]
TNEALFDVASHFALEGTVDSIEPYGDGHINTTYLVTTDGPRYILQRMNTG
IFPDTVNLMRNVELVTSTLKAQGKETLDIVRTTSGDTWAEIDGGAWRVYK
FIEHTMSYNLVPNPDVFREAGRAFGDFQNFLSGFDANQLTETIAHFHDTP
HRFEDFKKALAADELGRAAGCGPEIEFYLSHADQYAVVMDGLRDGSIPLR
VTHNDTKLNNILMDATTGKARAIIDLDTIMPGSMLFDFGDSIRFGASTAL
EDERDLDKVHFSTELFRAYTEGFVGELRDSITAREAELLPFSGNLLTMEC
GMRFLADYLEGDVYFATKYPEHNLVRSRTQIKLVREMEQRADETRAIVAD
VMETT
3D structure
PDB4ocv Insights into the binding specificity and catalytic mechanism of N-acetylhexosamine 1-phosphate kinases through multiple reaction complexes.
ChainA
Resolution1.472 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.162: N-acetylhexosamine 1-kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ANP A Y27 G30 H31 I32 N33 I46 Q48 F104 I105 K210 I227 Y24 G27 H28 I29 N30 I43 Q45 F101 I102 K207 I224 PDBbind-CN: -logKd/Ki=5.08,Kd=8.3uM
Gene Ontology
Molecular Function
GO:0004413 homoserine kinase activity
GO:0016740 transferase activity
Biological Process
GO:0009088 threonine biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4ocv, PDBe:4ocv, PDBj:4ocv
PDBsum4ocv
PubMed24816108
UniProtB7GN78

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