Structure of PDB 4oct Chain A

Receptor sequence
>4octA (length=209) Species: 9606 (Homo sapiens) [Search protein sequence]
QKEEEARKVKSGIRQMRLFSQDECAKIEARIDEVVSRAEKGLYNEHTVDR
APLRNKYFFGEGYTRGPGQERLYPPGDVDEIPEWVHQLVIQKLVEHRVIP
EGFVNSAVINDYQPGGCIVSHVDPIHIFERPIVSVSFFSDSALCFGCKFQ
FKPIRVSEPVLSLPVRRGSVTVLSGYAADEITHCIRPQDIKERRAVIILR
KTRLDAPRL
3D structure
PDB4oct Structures of human ALKBH5 demethylase reveal a unique binding mode for specific single-stranded N6-methyladenosine RNA demethylation.
ChainA
Resolution2.28 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.53: mRNA N(6)-methyladenine demethylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A H204 D206 H266 H121 D123 H183
BS02 AKG A N193 Y195 H204 D206 H266 I268 R277 V279 I281 N110 Y112 H121 D123 H183 I185 R194 V196 I198 MOAD: ic50=9uM
PDBbind-CN: -logKd/Ki=5.05,Kd=9uM
Gene Ontology
Molecular Function
GO:0035515 oxidative RNA demethylase activity
Biological Process
GO:0006397 mRNA processing

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Molecular Function
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Biological Process
External links
PDB RCSB:4oct, PDBe:4oct, PDBj:4oct
PDBsum4oct
PubMed24778178
UniProtQ6P6C2|ALKB5_HUMAN RNA demethylase ALKBH5 (Gene Name=ALKBH5)

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