Structure of PDB 4obv Chain A

Receptor sequence

>4obvA (length=471) Species: 411470 (Mediterraneibacter gnavus ATCC 29149)

TEYILNSTQLEEAIKSFVHDFCAEKHEIHDQPVVVEAKEHQEDKIKQIKI
PEKGRPVNEVVSEMMNEVYRYRGDANHPRFFSFVPGPASSVSWLGDIMTS
AYNIHAGGSKLAPMVNCIEQEVLKWLAKQVGFTENPGGVFVSGGSMANIT
ALTAARDNKLTDINLHLGTAYISDQTHSSVAKGLRIIGITDSRIRRIPTN
SHFQMDTTKLEEAIETDKKSGYIPFVVIGTAGTTNTGSIDPLTEISALCK
KHDMWFHIDGAYGASVLLSPKYKSLLTGTGLADSISWDAHKWLFQTYGCA
MVLVKDIRNLFHSFHVNPEYLKDLEDNVNTWDIGMELTRPARGLKLWLTL
QVLGSDLIGSAIEHGFQLAVWAEEALNPKKDWEIVSPAQMAMINFRYAPK
DLTKEEQDILNEKISHRILESGYAAIFTTVLNGKTVLRICAIHPEATQED
MQHTIDLLDQYGREIYTEMKK

3D structure

• PDB: 4obv Discovery and Characterization of Gut Microbiota Decarboxylases that Can Produce the Neurotransmitter Tryptamine.
• Chain: A
• Resolution: 2.84 Å

Enzymatic activity

• Enzyme Commision number: 4.1.1.105: L-tryptophan decarboxylase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	3SO	A	H120 W349 T356	H105 W331 T338
BS02	2SU	A	P102 A103 S105 F309 P462 E463	P87 A88 S90 F294 P444 E445
BS03	3SO	A	F98 V99 G159 S160 H192 T249 D274 A276 D303 K306	F83 V84 G144 S145 H177 T234 D259 A261 D288 K291

Gene Ontology

Molecular Function

• GO:0004058 aromatic-L-amino-acid decarboxylase activity
• GO:0016830 carbon-carbon lyase activity
• GO:0016831 carboxy-lyase activity
• GO:0030170 pyridoxal phosphate binding
• GO:0036469 L-tryptophan decarboxylase activity

Biological Process

• GO:0006520 amino acid metabolic process
• GO:0006568 tryptophan metabolic process
• GO:0019752 carboxylic acid metabolic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:4obv, PDBe:4obv, PDBj:4obv
• PDBsum: 4obv
• PubMed: 25263219
• UniProt: A7B1V0|TRPDC_MEDG7 Tryptophan decarboxylase (Gene Name=RUMGNA_01526)