Structure of PDB 4obr Chain A

Receptor sequence
>4obrA (length=595) Species: 9606 (Homo sapiens) [Search protein sequence]
APHLVQVDAARALWPLRRFWRSTGFCPPYVLSWDQQLNLAYVGAVPHRGI
KQVRTHWLLELVTTLSYNFTHLDGYLDLLRENQLLPGFELMGSASGHFTD
FEDKQQVFEWKDLVSSLARRYIGRYGLAHVSKWNFETWNEPDHHDFDNVS
MTMQGFLNYYDACSEGLRAASPALRLGGPGDSFHTPPRSPLSWGLLRHCH
DGTNFFTGEAGVRLDYISLHRKGARSSISILEQEKVVAQQIRQLFPKFAD
TPIYNDEADPLVGWSLPQPWRADVTYAAMVVKVIAQHQNLLLANTTSAFP
YALLSNDNAFLSYHPHPFAQRTLTARFQVNNTRPPHVQLLRKPVLTAMGL
LALLDEEQLWAEVSQAGTVLDSNHTVGVLASAHRPQGPADAWRAAVLIYA
SDDTRAHPNRSVAVTLRLRGVPPGPGLVYVTRYLDNGLCSPDGEWRRLGR
PVFPTAEQFRRMRAAEDPVAAAPRPLPAGGRLTLRPALRLPSLLLVHVCA
RPEKPPGQVTRLRALPLTQGQLVLVWSDEHVGSKCLWTYEIQFSQDYTPV
SRKPSTFNLFVFSPDTGAVSGSYRVRALDYWARPGPFSDPVPYLE
3D structure
PDB4obr Crystal structure of human alpha-L-iduronidase complex with alpha-L-iduronic acid
ChainA
Resolution2.46 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.2.1.76: L-iduronidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MAN A H356 P357 H314 P315
BS02 IDR A H91 N181 E182 K264 E299 G305 W306 D349 R363 H56 N139 E140 K222 E257 G263 W264 D307 R321
Gene Ontology
Molecular Function
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
Biological Process
GO:0005975 carbohydrate metabolic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4obr, PDBe:4obr, PDBj:4obr
PDBsum4obr
PubMed
UniProtP35475|IDUA_HUMAN Alpha-L-iduronidase (Gene Name=IDUA)

[Back to BioLiP]