Structure of PDB 4ob0 Chain A

Receptor sequence
>4ob0A (length=203) Species: 1848 (Pseudonocardia thermophila) [Search protein sequence]
TENILRKSDEEIQKEITARVKALESMLIEQGILTTSMIDRMAEIYENEVG
PHLGAKVVVKAWTDPEFKKRLLADGTEACKELGIGGLQGEDMMWVENTDE
VHHVVVCTLCSCYPWPVLGLPPNWFKEPQYRSRVVREPRQLLKEEFGFEV
PPSKEIKVWDSSSEMRFVVLPQRPAGTDGWSEEELATLVTRESMIGVEPA
KAV
3D structure
PDB4ob0 The active site sulfenic acid ligand in nitrile hydratases can function as a nucleophile.
ChainA
Resolution1.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C108 C111 S112 C113
Catalytic site (residue number reindexed from 1) C107 C110 S111 C112
Enzyme Commision number 4.2.1.84: nitrile hydratase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CO A C108 A111 S112 C113 C107 A110 S111 C112
BS02 PBC A Q89 A111 S112 C113 Q88 A110 S111 C112 MOAD: Ki=5uM
PDBbind-CN: -logKd/Ki=5.30,Ki=5.0uM
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0005515 protein binding
GO:0016829 lyase activity
GO:0018822 nitrile hydratase activity
GO:0046872 metal ion binding
GO:0046914 transition metal ion binding
GO:0050897 cobalt ion binding
GO:0080109 indole-3-acetonitrile nitrile hydratase activity
Biological Process
GO:0050899 nitrile catabolic process
Cellular Component
GO:0005575 cellular_component

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Cellular Component
External links
PDB RCSB:4ob0, PDBe:4ob0, PDBj:4ob0
PDBsum4ob0
PubMed24383915
UniProtQ7SID2|NHAA_PSETH Cobalt-containing nitrile hydratase subunit alpha

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