Structure of PDB 4o8j Chain A

Receptor sequence
>4o8jA (length=341) Species: 70601 (Pyrococcus horikoshii OT3) [Search protein sequence]
MITIDGSYGEGGGQILRTSVALSTITGEPVRIVNIRANRPNPGLRPQHLH
AILALKHLANAEVKGAHVGSRELVFIPKKLEAKEISIDIGTAGSITLVLQ
ALLPAMVFAREKVKFRITGGTDVSWSPPVDYLSNVTLFALEKIGIHGEIR
VIRRGHYPKGGGIVEGYVEPWNEKRELVAKEYSRIIKIEGISHATNLPSH
VAERQARAAKDELLQLKVPIEIRTEISRSIGPGSGIVVWAETDCLRLGGD
ALGKKGKPAEIVGKEAAQELLDQLKPGHCVDKFLGDQLIPFLAFSGGVIW
VSEITNHLKTNIWVVESFLGRIFDVDGNVGEPGKIRVIRRV
3D structure
PDB4o8j Structure of RNA 3'-phosphate cyclase bound to substrate RNA.
ChainA
Resolution2.04 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E10 H307
Catalytic site (residue number reindexed from 1) E10 H307
Enzyme Commision number 6.5.1.4: RNA 3'-terminal-phosphate cyclase (ATP).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A G13 R17 R36 R39 P40 Q47 H48 T91 A92 G93 S94 V123 S124 W125 Y157 P158 G13 R17 R36 R39 P40 Q47 H48 T91 A92 G93 S94 V123 S124 W125 Y157 P158
BS02 ADN A L97 S126 P127 Y131 D250 F283 D286 Q287 H307 L97 S126 P127 Y131 D250 F283 D286 Q287 H307
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0003963 RNA-3'-phosphate cyclase activity
GO:0005524 ATP binding
GO:0016874 ligase activity
Biological Process
GO:0006396 RNA processing
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4o8j, PDBe:4o8j, PDBj:4o8j
PDBsum4o8j
PubMed25161314
UniProtO59198|RTCA_PYRHO RNA 3'-terminal phosphate cyclase (Gene Name=rtcA)

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