Structure of PDB 4o8a Chain A

Receptor sequence
>4o8aA (length=462) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
QSVSRAAITAAYRRPETEAVSMLLEQARLPQPVAEQAHKLAYQLADKLRN
QKNASGRAGMVQGLLSLSSQEGVALMCLAEALLRIPDKATRDALLIRKGV
DMAMRLMGEQFVTGETIAEALANARKLEEKGFRYSYDMLGEAALTAADAQ
AYMVSYQQAIHAIGKASNGRGIYEGPGISIKLSALHPRYSRAQYDRVMEE
LYPRLKSLTLLARQYDIGINIDAEESDRLEISLDLLEKLCFEPELAGWNG
IGFVIQAYQKRCPLVIDYLIDLATRSRRRLMIRLVKGAYWDSEIKRAQMD
GLEGYPVYTRKVYTDVSYLACAKKLLAVPNLIYPQFATHNAHTLAAIYQL
AGQNYYPGQYEFQCLHGMGEPLYEQVTGKVADGKLNRPCRIYAPVGTHET
LLAYLVRRLLENGANTSFVNRIADTSLPLDELVADPVTAVEKLAQQEGQT
GLPHPKIPLPRD
3D structure
PDB4o8a Structure of the proline dehydrogenase domain of the multifunctional PutA flavoprotein.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.2.1.88: L-glutamate gamma-semialdehyde dehydrogenase.
1.5.5.2: proline dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD A D370 A371 V402 Q404 R431 V433 K434 G435 A436 Y437 W438 Y456 T457 R458 K459 T462 A485 T486 N488 C512 L513 E559 S565 F566 D222 A223 V254 Q256 R283 V285 K286 G287 A288 Y289 W290 Y308 T309 R310 K311 T314 A337 T338 N340 C364 L365 E411 S417 F418
Gene Ontology
Molecular Function
GO:0003842 1-pyrroline-5-carboxylate dehydrogenase activity
GO:0004657 proline dehydrogenase activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0006562 proline catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4o8a, PDBe:4o8a, PDBj:4o8a
PDBsum4o8a
PubMed12514740
UniProtP09546|PUTA_ECOLI Bifunctional protein PutA (Gene Name=putA)

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