Structure of PDB 4o7w Chain A

Receptor sequence
>4o7wA (length=232) Species: 70601 (Pyrococcus horikoshii OT3) [Search protein sequence]
VYEGKAKKMIPIDDDKLIMEFKDDATAFDGTKKARFKGKGWLNAQLSVIF
FKLLEEHGIKTHFIGVAGGNRLIVEKLDMYPLEVVVRNVVAGSLKKRLPL
PEGYELPEPIVELYYKNDELHDPMINYYHAKVLGISLDEIKKIEEIALKV
NEILKDYLAKKGIILVDFKLEFGKDKNGDIVLADEISPDTCRFWDAKTKR
SLDKDVFRFDKGDLIEAYKEIYERITGEKPEF
3D structure
PDB4o7w SAICAR synthetase (Type-2) in complex with ATP and TDP
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.3.2.6: phosphoribosylaminoimidazolesuccinocarboxamide synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TYD A E89 R93 G98 S99 D173 K175 C197 R198 R214 E83 R87 G92 S93 D167 K169 C191 R192 R208
BS02 ATP A G10 K11 K13 M15 H68 E81 L83 M85 K122 E177 D190 G4 K5 K7 M9 H62 E75 L77 M79 K116 E171 D184
Gene Ontology
Molecular Function
GO:0004639 phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GO:0005524 ATP binding
GO:0016874 ligase activity
Biological Process
GO:0006164 purine nucleotide biosynthetic process
GO:0006189 'de novo' IMP biosynthetic process
GO:0009236 cobalamin biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4o7w, PDBe:4o7w, PDBj:4o7w
PDBsum4o7w
PubMed
UniProtO57978|PUR7_PYRHO Phosphoribosylaminoimidazole-succinocarboxamide synthase (Gene Name=purC)

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