Structure of PDB 4o7v Chain A

Receptor sequence
>4o7vA (length=228) Species: 70601 (Pyrococcus horikoshii OT3) [Search protein sequence]
KAKKMIPIDDDKLIMEFKDDATAFDGTKKARFKGKGWLNAQLSVIFFKLL
EEHGIKTHFIGVAGGNRLIVEKLDMYPLEVVVRNVVAGSLKKRLPLPEGY
ELPEPIVELYYKNDELHDPMINYYHAKVLGISLDEIKKIEEIALKVNEIL
KDYLAKKGIILVDFKLEFGKDKNGDIVLADEISPDTCRFWDAKTKRSLDK
DVFRFDKGDLIEAYKEIYERITGEKPEF
3D structure
PDB4o7v SAICAR synthetase (Type-2) in complex with ADP and UDP/UMP
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.3.2.6: phosphoribosylaminoimidazolesuccinocarboxamide synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UDP A R93 G98 S99 D173 K175 T196 C197 R198 R214 R83 G88 S89 D163 K165 T186 C187 R188 R204
BS02 ADP A K13 M15 H68 E81 L83 M85 K122 E177 D190 K3 M5 H58 E71 L73 M75 K112 E167 D180
BS03 U5P A E89 R93 S99 D173 K175 T196 C197 R198 R214 E79 R83 S89 D163 K165 T186 C187 R188 R204
Gene Ontology
Molecular Function
GO:0004639 phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GO:0005524 ATP binding
GO:0016874 ligase activity
Biological Process
GO:0006164 purine nucleotide biosynthetic process
GO:0006189 'de novo' IMP biosynthetic process
GO:0009236 cobalamin biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4o7v, PDBe:4o7v, PDBj:4o7v
PDBsum4o7v
PubMed
UniProtO57978|PUR7_PYRHO Phosphoribosylaminoimidazole-succinocarboxamide synthase (Gene Name=purC)

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