Structure of PDB 4o7t Chain A

Receptor sequence
>4o7tA (length=225) Species: 70601 (Pyrococcus horikoshii OT3) [Search protein sequence]
AKKMIPIDDDKLIMEFKDDATAFDGTKKARFKGKGWLNAQLSVIFFKLLE
EHGIKTHFIGVAGGNRLIVEKLDMYPLEVVVRNVVAGSLKKRLPLPEGYE
LPEPIVELYYKNDELHDPMINYYHAKVLGISLDEIKKIEEIALKVNEILK
DYLAKKGIILVDFKLEFGKDKNGDIVLADEISPDTCRFWDAKTKRSLDKD
VFRFDKGDLIEAYKEIYERITGEKP
3D structure
PDB4o7t SAICAR synthetase (Type-2) in complex with ADP, ASP and TMP
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.3.2.6: phosphoribosylaminoimidazolesuccinocarboxamide synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TMP A R93 G98 S99 D173 K175 T196 C197 R198 R82 G87 S88 D162 K164 T185 C186 R187
BS02 ADP A K13 M15 H68 E81 L83 M85 K122 E177 D190 K2 M4 H57 E70 L72 M74 K111 E166 D179
BS03 ASP A A33 F34 D35 K210 R214 A22 F23 D24 K199 R203
Gene Ontology
Molecular Function
GO:0004639 phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GO:0005524 ATP binding
GO:0016874 ligase activity
Biological Process
GO:0006164 purine nucleotide biosynthetic process
GO:0006189 'de novo' IMP biosynthetic process
GO:0009236 cobalamin biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4o7t, PDBe:4o7t, PDBj:4o7t
PDBsum4o7t
PubMed
UniProtO57978|PUR7_PYRHO Phosphoribosylaminoimidazole-succinocarboxamide synthase (Gene Name=purC)

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