Structure of PDB 4o7s Chain A

Receptor sequence
>4o7sA (length=224) Species: 70601 (Pyrococcus horikoshii OT3) [Search protein sequence]
MIPIDDDKLIMEFKDDATAFDGTKKARFKGKGWLNAQLSVIFFKLLEEHG
IKTHFIGVAGGNRLIVEKLDMYPLEVVVRNVVAGSLKKRLPLPEGYELPE
PIVELYYKNDELHDPMINYYHAKVLGISLDEIKKIEEIALKVNEILKDYL
AKKGIILVDFKLEFGKDKNGDIVLADEISPDTCRFWDAKTKRSLDKDVFR
FDKGDLIEAYKEIYERITGEKPEF
3D structure
PDB4o7s SAICAR synthetase (Type-2) in complex with TMP/TDP
ChainA
Resolution2.24 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.3.2.6: phosphoribosylaminoimidazolesuccinocarboxamide synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TYD A E89 R93 G98 S99 D173 K175 C197 R198 R214 E75 R79 G84 S85 D159 K161 C183 R184 R200
BS02 TMP A E89 V91 R93 S99 D173 K175 C197 R198 E75 V77 R79 S85 D159 K161 C183 R184
Gene Ontology
Molecular Function
GO:0004639 phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GO:0005524 ATP binding
GO:0016874 ligase activity
Biological Process
GO:0006164 purine nucleotide biosynthetic process
GO:0006189 'de novo' IMP biosynthetic process
GO:0009236 cobalamin biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4o7s, PDBe:4o7s, PDBj:4o7s
PDBsum4o7s
PubMed
UniProtO57978|PUR7_PYRHO Phosphoribosylaminoimidazole-succinocarboxamide synthase (Gene Name=purC)

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