Structure of PDB 4o7e Chain A

Receptor sequence
>4o7eA (length=127) Species: 9606 (Homo sapiens) [Search protein sequence]
SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVK
LNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNK
PGDDIVLMAEALEKLFLQKINELPTEE
3D structure
PDB4o7e Acetyl-lysine Binding Site of Bromodomain-Containing Protein 4 (BRD4) Interacts with Diverse Kinase Inhibitors.
ChainA
Resolution1.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2RN A W81 V87 L92 W40 V46 L51 MOAD: ic50=5.7uM
PDBbind-CN: -logKd/Ki=5.24,IC50=5.7uM
BS02 2RN A F79 D145 M149 F38 D104 M108 MOAD: ic50=5.7uM
PDBbind-CN: -logKd/Ki=5.24,IC50=5.7uM
BS03 2RN A W81 K91 L92 W40 K50 L51 MOAD: ic50=5.7uM
PDBbind-CN: -logKd/Ki=5.24,IC50=5.7uM
External links
PDB RCSB:4o7e, PDBe:4o7e, PDBj:4o7e
PDBsum4o7e
PubMed24568369
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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