Structure of PDB 4o74 Chain A

Receptor sequence
>4o74A (length=127) Species: 9606 (Homo sapiens) [Search protein sequence]
SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVK
LNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNK
PGDDIVLMAEALEKLFLQKINELPTEE
3D structure
PDB4o74 Acetyl-lysine Binding Site of Bromodomain-Containing Protein 4 (BRD4) Interacts with Diverse Kinase Inhibitors.
ChainA
Resolution1.45 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 R78 A W81 P82 V87 L92 Y97 Y139 N140 I146 W40 P41 V46 L51 Y56 Y98 N99 I105 MOAD: ic50=0.025uM
PDBbind-CN: -logKd/Ki=7.60,IC50=25nM
BindingDB: IC50=25nM,Kd=37nM,Ki=56nM
External links
PDB RCSB:4o74, PDBe:4o74, PDBj:4o74
PDBsum4o74
PubMed24568369
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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