Structure of PDB 4o72 Chain A

Receptor sequence
>4o72A (length=127) Species: 9606 (Homo sapiens) [Search protein sequence]
SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVK
LNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNK
PGDDIVLMAEALEKLFLQKINELPTEE
3D structure
PDB4o72 Acetyl-lysine Binding Site of Bromodomain-Containing Protein 4 (BRD4) Interacts with Diverse Kinase Inhibitors.
ChainA
Resolution1.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2R4 A W81 P82 F83 V87 L92 N140 I146 W40 P41 F42 V46 L51 N99 I105 MOAD: ic50=1uM
PDBbind-CN: -logKd/Ki=6.00,IC50=1.0uM
BindingDB: IC50=1000nM
External links
PDB RCSB:4o72, PDBe:4o72, PDBj:4o72
PDBsum4o72
PubMed24568369
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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