Structure of PDB 4o70 Chain A

Receptor sequence
>4o70A (length=127) Species: 9606 (Homo sapiens) [Search protein sequence]
SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVK
LNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNK
PGDDIVLMAEALEKLFLQKINELPTEE
3D structure
PDB4o70 Acetyl-lysine Binding Site of Bromodomain-Containing Protein 4 (BRD4) Interacts with Diverse Kinase Inhibitors.
ChainA
Resolution1.55 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1QK A W81 F83 N140 D144 D145 I146 W40 F42 N99 D103 D104 I105 MOAD: ic50=19uM
PDBbind-CN: -logKd/Ki=4.72,IC50=19uM
BS02 1QK A K91 N93 K50 N52 MOAD: ic50=19uM
PDBbind-CN: -logKd/Ki=4.72,IC50=19uM
External links
PDB RCSB:4o70, PDBe:4o70, PDBj:4o70
PDBsum4o70
PubMed24568369
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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