Structure of PDB 4o6z Chain A

Receptor sequence
>4o6zA (length=448) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence]
HPFTPGMFNNDPLQKYDKELFDLLEKEKNRQIETINLIASENLTNTAVRE
CLGDRISNKYSEGYPHKRYYGGNDYVDKIEELCYKRALEAFNVSEEEWGV
NVQPLSGSAANVQALYALVGVKGKIMGMHLCSGGHLTHGFFDEKKKVSIT
SDLFESKLYKCNSEGYVDMESVRNLALSFQPKVIICGYTSYPRDIDYKGF
REICDEVNAYLFADISHISSFVACNLLNNPFTYADVVTTTTHKILRGPRS
ALIFFNKKRNPGIDQKINSSVFPSFQGGPHNNKIAAVACQLKEVNTPEFK
EYTKQVLLNSKALAECLLKRNLDLVTNGTDNHLIVVDLRKYNITGSKLQE
TCNAINIALNKNTIPSDVDCVSPSGIRIGTPALTTRGCKEKDMEFIADML
LKAILLTDELQQKYGKKLVDFKKGLVNNPKIDELKKEVVQWAKNLPFA
3D structure
PDB4o6z The structure of Plasmodium falciparum serine hydroxymethyltransferase reveals a novel redox switch that regulates its activities.
ChainA
Resolution2.98 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y54 E56 D208 T234 K237 R243
Catalytic site (residue number reindexed from 1) Y60 E62 D214 T240 K243 R249
Enzyme Commision number 2.1.2.1: glycine hydroxymethyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PLP A S100 G101 S102 H129 D208 S210 H211 H236 K237 S106 G107 S108 H135 D214 S216 H217 H242 K243
Gene Ontology
Molecular Function
GO:0004372 glycine hydroxymethyltransferase activity
GO:0008168 methyltransferase activity
GO:0030170 pyridoxal phosphate binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0006730 one-carbon metabolic process
GO:0019264 glycine biosynthetic process from serine
GO:0032259 methylation
GO:0035999 tetrahydrofolate interconversion
GO:0046653 tetrahydrofolate metabolic process
GO:0070178 D-serine metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0020011 apicoplast

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4o6z, PDBe:4o6z, PDBj:4o6z
PDBsum4o6z
PubMed24914963
UniProtQ8I566|GLYA_PLAF7 Serine hydroxymethyltransferase (Gene Name=SHMT)

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