Structure of PDB 4o6l Chain A

Receptor sequence
>4o6lA (length=260) Species: 9606 (Homo sapiens) [Search protein sequence]
NECISVKGRIYSILKQIGSGGSSKVFQVLNEKKQIYAIKYVNLEEADNQT
LDSYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYMVMECGNIDLNSWLK
KKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVDGMLKLID
FGIANQMQPDTTSTVNYMPPEAIKDMSISPKSDVWSLGCILYYMTYGKTP
FQQIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRISIP
ELLAHPYVQI
3D structure
PDB4o6l Crystal Structure of TTK kinase domain with an inhibitor: 401498
ChainA
Resolution2.38 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D647 K649 N652 D664 D674 T686
Catalytic site (residue number reindexed from 1) D133 K135 N138 D150 D160 T164
Enzyme Commision number 2.7.12.1: dual-specificity kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2QK A I531 V539 A551 K553 I586 M602 G605 I607 L654 I663 D664 Q670 M671 T675 I17 V25 A37 K39 I72 M88 G91 I93 L140 I149 D150 Q156 M157 T161 BindingDB: IC50=1.9nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4o6l, PDBe:4o6l, PDBj:4o6l
PDBsum4o6l
PubMed
UniProtP33981|TTK_HUMAN Dual specificity protein kinase TTK (Gene Name=TTK)

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