Structure of PDB 4o6a Chain A

Receptor sequence
>4o6aA (length=361) Species: 10090 (Mus musculus) [Search protein sequence]
MPDKLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQKRESEFKGVEQL
NTGSYYEHVKISAPNEFDVMFKLEVPRIELQEYYETGAFYLVKFKRIPRG
NPLSHFLEGEVLSATKMLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVT
LLIRNPEEISVDIILALESKGSWPISTKEGLPIQGWLGTKVRTNLRREPF
YLVPKNAKDGNSFQGETWRLSFSHTEKYILNNHGIEKTCCESSGAKCCRK
ECLKLMKYLLEQLKKEFQELDAFCSYHVKTAIFHMWTQDPQDSQWDPRNL
SSCFDKLLAFFLECLRTEKLDHYFIPKFNLFSQELIDRKSKEFLSKKIEY
ERNNGFPIFDK
3D structure
PDB4o6a The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop.
ChainA
Resolution1.859 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.86: cyclic GMP-AMP synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A R158 L159 K160 R161 K184 H203 E386 K395 R13 L14 K15 R16 K39 H58 E241 K250
BS02 dna A S165 A168 Y200 K372 S20 A23 Y55 K227
BS03 dna A T334 K335 T338 T189 K190 T193
BS04 dna A K315 R342 K170 R197
BS05 ZN A H378 C384 C385 C392 H233 C239 C240 C247
External links
PDB RCSB:4o6a, PDBe:4o6a, PDBj:4o6a
PDBsum4o6a
PubMed24462292
UniProtQ8C6L5|CGAS_MOUSE Cyclic GMP-AMP synthase (Gene Name=Cgas)

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