Structure of PDB 4o56 Chain A

Receptor sequence
>4o56A (length=244) Species: 9606 (Homo sapiens) [Search protein sequence]
LGSPGIQGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIF
WVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGT
ESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLP
YLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDF
RTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS
3D structure
PDB4o56 Integration of Charge-dipole Interaction and Intramolecular Hydrogen Bond in Ligand Design for the Polo-Box Domain of Polo-like Kinase 1
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.21: polo kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K413 W414 D416 S487 H489 L490 L491 R516 F535 H538 K540 K54 W55 D57 S128 H130 L131 L132 R157 F176 H179 K181
External links
PDB RCSB:4o56, PDBe:4o56, PDBj:4o56
PDBsum4o56
PubMed
UniProtP53350|PLK1_HUMAN Serine/threonine-protein kinase PLK1 (Gene Name=PLK1)

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