Structure of PDB 4o4e Chain A

Receptor sequence
>4o4eA (length=246) Species: 885318 (Entamoeba histolytica HM-1:IMSS-A) [Search protein sequence]
GSFTQQPDGQYLLKPCLSHRERDFYLHIKDDKEWTGTGIIPKFYGVELHE
FGFGELEFIRMENLMYKYKRPFVLDLKIGTQTWDPETASSKMKKRLVVDS
TSTTTSLGVRFSGMERNIGEEKPILYSRYLCTHEVNTRDSLKEYIKLFFN
DGKKYRKELVPYFISQLDKMIEVMKKREYKMFSSSVLFVYDSTTTLEDKK
YNCKMIDFAHNWILSEEECTVEDGFLFGLNNLKSILEDIENEFKSL
3D structure
PDB4o4e IP6K structure and the molecular determinants of catalytic specificity in an inositol phosphate kinase family.
ChainA
Resolution1.9 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.7.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5MY A G23 Q27 K101 K115 K118 R119 R152 Y153 G1 Q5 K77 K91 K94 R95 R128 Y129
BS02 ATP A G23 S24 F25 Q27 L36 K38 N87 L88 I230 D231 G1 S2 F3 Q5 L12 K14 N63 L64 I206 D207
Gene Ontology
Molecular Function
GO:0000828 inositol hexakisphosphate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0046872 metal ion binding
Biological Process
GO:0016310 phosphorylation
GO:0032958 inositol phosphate biosynthetic process
GO:0046854 phosphatidylinositol phosphate biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4o4e, PDBe:4o4e, PDBj:4o4e
PDBsum4o4e
PubMed24956979
UniProtN9UNA8

[Back to BioLiP]