Structure of PDB 4o4d Chain A

Receptor sequence
>4o4dA (length=240) Species: 885318 (Entamoeba histolytica HM-1:IMSS-A) [Search protein sequence]
PDGQYLLKPCLSHRERDFYLHIKDDKEWTGTGIIPKFYGVELHEFGFGEL
EFIRMENLMYKYKRPFVLDLKIGTQTWDPETASSKMKKRLVVDSTSTTTS
LGVRFSGMERNIGEEKPILYSRYLCTHEVNTRDSLKEYIKLFFNDGKKYR
KELVPYFISQLDKMIEVMKKREYKMFSSSVLFVYDSTTTLEDKKYNCKMI
DFAHNWILSEEECTVEDGFLFGLNNLKSILEDIENEFKSL
3D structure
PDB4o4d IP6K structure and the molecular determinants of catalytic specificity in an inositol phosphate kinase family.
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 I3P A K115 K118 R119 R152 Y153 H234 K85 K88 R89 R122 Y123 H204
BS02 ATP A L36 K38 E86 N87 L88 D99 D231 L6 K8 E56 N57 L58 D69 D201
Gene Ontology
Molecular Function
GO:0000828 inositol hexakisphosphate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0046872 metal ion binding
Biological Process
GO:0016310 phosphorylation
GO:0032958 inositol phosphate biosynthetic process
GO:0046854 phosphatidylinositol phosphate biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:4o4d, PDBe:4o4d, PDBj:4o4d
PDBsum4o4d
PubMed24956979
UniProtN9UNA8

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