Structure of PDB 4o3t Chain A

Receptor sequence
>4o3tA (length=219) Species: 9606 (Homo sapiens) [Search protein sequence]
NIGWMVSLRYRNKHICGGSLIKESWVLTARQCFPSRDLKDYEAWLGIHDV
HGRGDEKCKQVLNVSQLVYGPEGSDLVLMKLARPAVLDDFVSTIDLPNYG
STIPEKTSCSVYGWGYTGLINYDGLLRVAHLYIMGNEKCSQHHRGKVTLN
ESEICAGAEKIGSGPCEGDYGGPLVCEQHKMRMVLGVIVPGRGCAIPNRP
GIFVRVAYYAKWIHKIILT
3D structure
PDB4o3t An allosteric switch for pro-HGF/Met signaling using zymogen activator peptides.
ChainA
Resolution2.99 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Q534 D578 E670 G671 D672 Y673 G674
Catalytic site (residue number reindexed from 1) Q31 D75 E167 G168 D169 Y170 G171
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A I505 H551 G616 Y619 T620 L629 R630 V631 H633 S666 G667 D672 A698 I2 H48 G113 Y116 T117 L126 R127 V128 H130 S163 G164 D169 A195
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:4o3t, PDBe:4o3t, PDBj:4o3t
PDBsum4o3t
PubMed24859116
UniProtP14210|HGF_HUMAN Hepatocyte growth factor (Gene Name=HGF)

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