Structure of PDB 4o27 Chain A

Receptor sequence
>4o27A (length=325) Species: 9606 (Homo sapiens) [Search protein sequence]
MASPADIVKNLKESMAVLEKQDISDKKAEKATEEVSKNLVAMKEILYGTN
EKEPQTEAVAQLAQELYNSGLLSTLVADLQLIDFEGKKDVAQIFNNILRR
QIGTRTPTVEYICTQQNILFMLLKGYESPEIALNCGIMLRECIRHEPLAK
IILWSEQFYDFFRYVEMSTFDIASDAFATFKDLLTRHKLLSAEFLEQHYD
RFFSEYEKLLHSENYVTKRQSLKLLGELLLDRHNFTIMTKYISKPENLKL
MMNLLRDKSRNIQFEAFHVFKVFVANPNKTQPILDILLKNQAKLIEFLSK
FQNDRTEDEQFNDEKTYLVKQIRDL
3D structure
PDB4o27 Structural insights into regulatory mechanisms of MO25-mediated kinase activation.
ChainA
Resolution3.185 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K257 M260 I294 N298 K301 L302 K249 M252 I286 N290 K293 L294
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0019900 kinase binding
GO:0030295 protein kinase activator activity
GO:0043539 protein serine/threonine kinase activator activity
Biological Process
GO:0007165 signal transduction
GO:0010800 positive regulation of peptidyl-threonine phosphorylation
GO:0014823 response to activity
GO:0018105 peptidyl-serine phosphorylation
GO:0035556 intracellular signal transduction
GO:0071476 cellular hypotonic response
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0097066 response to thyroid hormone
GO:1901017 negative regulation of potassium ion transmembrane transporter activity
GO:1901380 negative regulation of potassium ion transmembrane transport
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0030018 Z disc
GO:0032991 protein-containing complex
GO:0034774 secretory granule lumen
GO:0070062 extracellular exosome
GO:1902554 serine/threonine protein kinase complex
GO:1904813 ficolin-1-rich granule lumen

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4o27, PDBe:4o27, PDBj:4o27
PDBsum4o27
PubMed24746913
UniProtQ9Y376|CAB39_HUMAN Calcium-binding protein 39 (Gene Name=CAB39)

[Back to BioLiP]