Structure of PDB 4o1p Chain A

Receptor sequence

>4o1pA (length=672) Species: 9823 (Sus scrofa)

SLEEMLTQAVQEADIEQVRQLLERGADANFQEEEWGWSPLHSAVQMDSED
LVALLLKHGADPCLRKRNGATPFIIAGITGNVRLLQLLLPNVEDVNECDV
NGFTAFMEAAVYGRVEALRFLYENGADVNMHRKTKQDQERIRKGGATALM
DAAEKGHVGVVTILLHAMKAEVDARDNMGRNALVYALLNPDDGKAKAITR
LLLDHGADVNVRGEGSKTPLILAVERKNLDLVQMLLEQEQIEVNDTDREG
KTALLLAVELRLEEIAKLLCHRGASTNCGDLVAIARRNYDSDLVKFLRLH
NWKPQSSRWGEALKHLHRIWRPMIGKLKIFIDEEYKIADTAEGGIYLGLY
EDQEVAVKRFSEGSTRGQQEVSCLQSSRANDNVVTFYGSESDGSCLHVCL
ALCEYTLQEHLANHRGDAVPNEEDESARNILSSLFKAIGELHRSGYSHQD
LQPQNILIDSKNGTFLADFDKSIKWAEDPQKIKRDLEALGLLVLYVVKKG
DISFETLKNQSFEEVIQGSPDEETRDLIHHLFHPEDRLSSLLAHPFFWSW
ESRYRTLRDVGNESDIKTRNQNSRILQLLQPGTLSTSFAQWTTKIDSFVM
EEMNAYQDTLGDLLKFIRNLGEHINEQKNKKMKSIIGEPSQYFQEKFPDL
VMYVYTKLQNTEYMKHFPKTHN

3D structure

• PDB: 4o1p Dimeric structure of pseudokinase RNase L bound to 2-5A reveals a basis for interferon-induced antiviral activity.
• Chain: A
• Resolution: 2.5 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ANP	A	A370 T372 I377 A388 K390 C435 Q486 L489 D500	A338 T340 I345 A356 K358 C403 Q454 L457 D468
BS02	MG	A	D500 D502	D468 D470
BS03	MG	A	N487 D500	N455 D468
BS04	25L	A	W56 W58 Q66 K87 N122 F124 E129 Y133 R153 K164	W35 W37 Q45 K66 N101 F103 E108 Y112 R132 K143
BS05	25L	A	R307 R308 Y310 R353	R286 R287 Y289 R321

Gene Ontology

Molecular Function

• GO:0004540 RNA nuclease activity
• GO:0004672 protein kinase activity
• GO:0005524 ATP binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006397 mRNA processing
• GO:0006468 protein phosphorylation

External links

• PDB: RCSB:4o1p, PDBe:4o1p, PDBj:4o1p
• PDBsum: 4o1p
• PubMed: 24462203
• UniProt: A5H025