Structure of PDB 4o0w Chain A

Receptor sequence
>4o0wA (length=259) Species: 9606 (Homo sapiens) [Search protein sequence]
KRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGV
EHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQK
LSKFDEQRTATYITELANALSYCHSKRVIYRDIKPENLLLGSAGELKIAD
FGWSVHLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEAN
TYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPW
ITANSSKPS
3D structure
PDB4o0w Functional Role of Conserved HxD-histidine in the Catalytic Core of Protein Kinase
ChainA
Resolution2.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D256 K258 E260 N261 D274 T292
Catalytic site (residue number reindexed from 1) D132 K134 E136 N137 D150 T160
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADN A L139 V147 A160 E211 T217 E260 L263 L15 V23 A36 E87 T93 E136 L139
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0000212 meiotic spindle organization
GO:0000226 microtubule cytoskeleton organization
GO:0000278 mitotic cell cycle
GO:0006468 protein phosphorylation
GO:0007052 mitotic spindle organization
GO:0007098 centrosome cycle
GO:0007100 mitotic centrosome separation
GO:0051321 meiotic cell cycle

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Molecular Function
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Biological Process
External links
PDB RCSB:4o0w, PDBe:4o0w, PDBj:4o0w
PDBsum4o0w
PubMed
UniProtO14965|AURKA_HUMAN Aurora kinase A (Gene Name=AURKA)

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