Structure of PDB 4o0t Chain A

Receptor sequence
>4o0tA (length=292) Species: 9606 (Homo sapiens) [Search protein sequence]
EEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQ
MNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGG
SLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRNIKSDNILLGMD
GSVKLTDFGFCAQITPEQSKRSEMVGTPYWMAPEVVTRKAYGPKVDIWSL
GIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNR
CLEMDVEKRGSAKELLQHQFLKIAKPLSSLTPLIAAAKEATK
3D structure
PDB4o0t Back Pocket Flexibility Provides Group II p21-Activated Kinase (PAK) Selectivity for Type I 1/2 Kinase Inhibitors.
ChainA
Resolution2.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N389 K391 D393 N394 D407 T427
Catalytic site (residue number reindexed from 1) N139 K141 D143 N144 D157 T177
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2OL A V284 A297 K299 E315 M319 M344 Y346 L347 L396 T406 D407 F408 V34 A47 K49 E65 M69 M94 Y96 L97 L146 T156 D157 F158 PDBbind-CN: -logKd/Ki=5.54,Ki=2.9uM
BindingDB: IC50=5420nM,Ki=2900nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4o0t, PDBe:4o0t, PDBj:4o0t
PDBsum4o0t
PubMed24432870
UniProtQ13153|PAK1_HUMAN Serine/threonine-protein kinase PAK 1 (Gene Name=PAK1)

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