Structure of PDB 4o08 Chain A

Receptor sequence
>4o08A (length=287) Species: 1404 (Priestia megaterium) [Search protein sequence]
MSKQYINVNGVNLHYISKGQGELMLFLHGFPDFSHIWRHQIDEFSNDFHT
VALDLRGYNLSEKPSGLESYEIDVLVEDIRQVIEGLGYSSCTLVVHDWGA
GIGWTFAYRYPEYVQKLIAFNGPHPYTFMRELRTNKNQQKASEYMKWFQK
QEVQDYMERDNFSGLRKLVIDPGVKKGYLTADDVQAYMNSWENGSVLSML
SYYRNLKIFTEEDLRRKSLFPLEEEVLNIPVQIIWGNQDPTFMPENLDGI
EEYVPNISVHRLAEASHAPQHEKPQEVNNVMWNFLNK
3D structure
PDB4o08 Engineering of an epoxide hydrolase for efficient bioresolution of bulky pharmaco substrates.
ChainA
Resolution1.95 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) F30 D97 W98 N121 L132 Y144 Y203 D239 H267
Catalytic site (residue number reindexed from 1) F30 D97 W98 N121 L132 Y144 Y203 D239 H267
Enzyme Commision number 3.2.2.10: pyrimidine-5'-nucleotide nucleosidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PO6 A D97 W98 P123 Y144 M145 Y203 D97 W98 P123 Y144 M145 Y203
BS02 PO6 A Q139 S142 K146 I208 L214 Q139 S142 K146 I208 L214
BS03 PO6 A V169 S266 H267 V169 S266 H267
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0016787 hydrolase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0047405 pyrimidine-5'-nucleotide nucleosidase activity

View graph for
Molecular Function
External links
PDB RCSB:4o08, PDBe:4o08, PDBj:4o08
PDBsum4o08
PubMed25331869
UniProtG9BEX6

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