Structure of PDB 4nzn Chain A

Receptor sequence
>4nznA (length=325) Species: 9606 (Homo sapiens) [Search protein sequence]
RQIVVGICSMAKKSKSKPMKEILERISLFKYITVVVFEEEVILNEPVENW
PLCDCLISFHSKGFPLDKAVAYAKLRNPFVINDLNMQYLIQDRREVYSIL
QAEGILLPRYAILNRDPNNPKECNLIEGEDHVEVNGEVFQKPFVEKPVSA
EDHNVYIYYPTSAGGGSQRLFRKIGSRSSVYSPESNVRKTGSYIYEEFMP
TDGTDVKVYTVGPDYAHAEARKSPALDGKVERDSEGKEVRYPVILNAREK
LIAWKVCLAFKQTVCGFDLLRANGQSYVCDVNGFSFVKNSMKYYDDCAKI
LGNIVMRELAPQFHIPWSIPLEAED
3D structure
PDB4nzn Synthetic Inositol Phosphate Analogs Reveal that PPIP5K2 Has a Surface-Mounted Substrate Capture Site that Is a Target for Drug Discovery.
ChainA
Resolution1.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.4.24: diphosphoinositol-pentakisphosphate 1-kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ANP A R134 V185 K187 H194 L211 E237 F239 M240 D246 S264 D309 L311 D321 N323 R93 V144 K146 H153 L170 E196 F198 M199 D205 S223 D268 L270 D280 N282
BS02 2OU A K53 K54 K103 E192 H194 R213 K12 K13 K62 E151 H153 R172 PDBbind-CN: -logKd/Ki=6.38,IC50=0.42uM
BS03 MG A D321 N323 D280 N282
BS04 MG A D309 D321 D268 D280
BS05 MG A S68 F70 I73 S27 F29 I32
Gene Ontology
Molecular Function
GO:0000829 diphosphoinositol pentakisphosphate kinase activity

View graph for
Molecular Function
External links
PDB RCSB:4nzn, PDBe:4nzn, PDBj:4nzn
PDBsum4nzn
PubMed24768307
UniProtO43314|VIP2_HUMAN Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 (Gene Name=PPIP5K2)

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