Structure of PDB 4nzm Chain A

Receptor sequence
>4nzmA (length=325) Species: 9606 (Homo sapiens) [Search protein sequence]
RQIVVGICSMAKKSKSKPMKEILERISLFKYITVVVFEEEVILNEPVENW
PLCDCLISFHSKGFPLDKAVAYAKLRNPFVINDLNMQYLIQDRREVYSIL
QAEGILLPRYAILNRDPNNPKECNLIEGEDHVEVNGEVFQKPFVEKPVSA
EDHNVYIYYPTSAGGGSQRLFRKIGSRSSVYSPESNVRKTGSYIYEEFMP
TDGTDVKVYTVGPDYAHAEARKSPALDGKVERDSEGKEVRYPVILNAREK
LIAWKVCLAFKQTVCGFDLLRANGQSYVCDVNGFSFVKNSMKYYDDCAKI
LGNIVMRELAPQFHIPWSIPLEAED
3D structure
PDB4nzm Synthetic Inositol Phosphate Analogs Reveal that PPIP5K2 Has a Surface-Mounted Substrate Capture Site that Is a Target for Drug Discovery.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.4.24: diphosphoinositol-pentakisphosphate 1-kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ANP A R134 V185 K187 H194 L211 R213 E237 E238 F239 M240 D246 D309 L311 D321 N323 R93 V144 K146 H153 L170 R172 E196 E197 F198 M199 D205 D268 L270 D280 N282
BS02 0EJ A K54 R213 K214 K248 R262 K329 K13 R172 K173 K207 R221 K288 PDBbind-CN: -logKd/Ki=6.85,IC50=0.14uM
BS03 MG A D321 N323 D280 N282
BS04 MG A D309 D321 D268 D280
BS05 MG A S68 F70 I73 S27 F29 I32
Gene Ontology
Molecular Function
GO:0000829 diphosphoinositol pentakisphosphate kinase activity

View graph for
Molecular Function
External links
PDB RCSB:4nzm, PDBe:4nzm, PDBj:4nzm
PDBsum4nzm
PubMed24768307
UniProtO43314|VIP2_HUMAN Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 (Gene Name=PPIP5K2)

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