Structure of PDB 4nzh Chain A

Receptor sequence
>4nzhA (length=448) Species: 746128 (Aspergillus fumigatus) [Search protein sequence]
LRSTPQDELHDLLCVGFGPASLAIAIALHDALDPRLNKSAAQPKICFLER
QKQFAWHSGMLVPGSKMQISFIKDLATLRDPRSSFTFLNYLHQKGRLIHF
TNLSTFLPARLEFEDYMRWCAQQFSDVVAYGEEVVEVIPGKSDPSSSVVD
FFTVRSRNVETGEISARRTRKVVIAIGGTAKMPSGLPQDPRIIHSSKYCT
TLPALLKDKSKPYNIAVLGSGQSAAEIFHDLQKRYPNSRTTLIMADSAMR
PSDDSPFVNEIFNPERVDKFYSQSAAERQRSLLADKATNYSVVRLELIEE
IYNDMYLQRVKNPDETQWQHRILPERKITRVEHHGPQSRMRIHLKSSKPE
KETLEVDALMVATGYNRNAHERLLSKVQHLRPTGQDQWKPHRDYRVEMDP
SKVSSEAGIWLQGCNERTHGLSDSLLSVLAVRGGEMVQSIFGEQLERA
3D structure
PDB4nzh A. fumigatus flavin-dependent ornithine monooxygenase R279A mutant
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.13.196: L-ornithine N(5)-monooxygenase [NAD(P)H].
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD A G48 P49 A50 E83 R84 Q85 W90 H91 Q102 I103 E167 V168 I210 G211 Y407 S466 L467 L468 G18 P19 A20 E49 R50 Q51 W56 H57 Q68 I69 E133 V134 I176 G177 Y365 S424 L425 L426
BS02 ORN A I103 K107 N293 F296 L467 S469 I69 K73 N259 F262 L425 S427
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004497 monooxygenase activity
GO:0004499 N,N-dimethylaniline monooxygenase activity
GO:0005506 iron ion binding
GO:0031172 ornithine N5-monooxygenase activity
GO:0070401 NADP+ binding
Biological Process
GO:0006696 ergosterol biosynthetic process
GO:0006879 intracellular iron ion homeostasis
GO:0009058 biosynthetic process
GO:0010106 cellular response to iron ion starvation
GO:0019290 siderophore biosynthetic process
GO:0031169 ferrichrome biosynthetic process
GO:0033214 siderophore-dependent iron import into cell
GO:0044550 secondary metabolite biosynthetic process
Cellular Component
GO:0005575 cellular_component

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4nzh, PDBe:4nzh, PDBj:4nzh
PDBsum4nzh
PubMed
UniProtE9QYP0|SIDA_ASPFU L-ornithine N(5)-monooxygenase (Gene Name=sidA)

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