Structure of PDB 4nyz Chain A

Receptor sequence
>4nyzA (length=460) Species: 12107 (Mengo virus) [Search protein sequence]
GALERLPDGPRIHVPRKTALRPTVARQVFQPAFAPAVLSKFDPRTDADVD
EVAFSKHTSNQETLPPVFRMVAREYANRVFALLGRDNGRLSVKQALDGLE
GMDPMDKNTSPGLPYTTLGMRRTDVVDWETATLIPFAAERLEKMNNKDFS
DIVYQTFLKDELRPIEKVQAAKTRIVDVPPFEHCILGRQLLGKFASKFQT
QPGLELGSAIGCDPDVHWTAFGVAMQGFERVYDVDYSNFDSTHSVAVFRL
LAEEFFSEENGFDPLVKDYLESLAISKHAYEEKRYLITGGLPSGCAATSM
LNTIMNNIIIRAGLYLTYKNFEFDDVKVLSYGDDLLVATNYQLNFDRVRT
SLAKTGYKITPANKTSTFPLESTLEDVVFLKRKFKKEGPLYRPVMNREAL
EAMLSYYRPGTLSEKLTSITMLAVHSGKQEYDRLFAPFREVGVIVPTFES
VEYRWRSLFW
3D structure
PDB4nyz The crystal structure of a cardiovirus RNA-dependent RNA polymerase reveals an unusual conformation of the polymerase active site
ChainA
Resolution2.15 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.22.28: picornain 3C.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLN A N238 S241 T242 H243 G290 L291 D333 N238 S241 T242 H243 G290 L291 D333
BS02 MG A K159 E161 R163 T173 R174 K159 E161 R163 T173 R174
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:4nyz, PDBe:4nyz, PDBj:4nyz
PDBsum4nyz
PubMed24600002
UniProtP12296|POLG_ENMGO Genome polyprotein

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