Structure of PDB 4nyf Chain A

Receptor sequence
>4nyfA (length=149) Species: 82834 (Human immunodeficiency virus type 1 lw12.3 isolate) [Search protein sequence]
SSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLA
GRWPVKTIHTDNGSNFTSATVKAACDWAGIKQEPQSQGVVESMNKELKKI
IGQVRDQAEHLKTAVQMAVFIHNKKRKGGIGGYSAGERIVDIIATDIQT
3D structure
PDB4nyf Discovery of BI 224436, a Noncatalytic Site Integrase Inhibitor (NCINI) of HIV-1.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.16: HIV-1 retropepsin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4BI A A169 E170 H171 T174 A108 E109 H110 T113 MOAD: Kd=49nM
PDBbind-CN: -logKd/Ki=7.31,Kd=49nM
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
Biological Process
GO:0015074 DNA integration

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Molecular Function
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Biological Process
External links
PDB RCSB:4nyf, PDBe:4nyf, PDBj:4nyf
PDBsum4nyf
PubMed24900852
UniProtP0C6F2|POL_HV1LW Gag-Pol polyprotein (Gene Name=gag-pol)

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