Structure of PDB 4nwj Chain A

Receptor sequence
>4nwjA (length=504) Species: 93061 (Staphylococcus aureus subsp. aureus NCTC 8325) [Search protein sequence]
AKKPTALIILDGFANRESEHGNAVKLANKPNFDRYYNKYPTTQIEASGLD
VGLPEGQMGNSEVGHMNIGAGRIVYQSLTRINKSIEDGDFFENDVLNNAI
AHVNSHDSALHIFGLLSDGGVHSHYKHLFALLELAKKQGVEKVYVHAFLD
GRDVDQKSALKYIEETEAKFNELGIGQFASVSGRYYAMDRDKRWEREEKA
YNAIRNFDAPTYATAKEGVEASYNEGLTDEFVVPFIVENQNDGVNDGDAV
IFYNFRPDRAAQLSEIFANRAFEGFKVEQVKDLFYATFTKYNDNIDAAIV
FEKVDLNNTIGEIAQNNNLTQLRIAETEKYPHVTYFMSGGRNEEFKGERR
RLIDSPKVATYDLKPEMSAYEVKDALLEELNKGDLDLIILNFANPDMVGH
SGMLEPTIKAIEAVDECLGEVVDKILDMDGYAIITADHGNSDQVLTDDDQ
PMTTHTTNPVPVIVTKEGVTLRETGRLGDLAPTLLDLLNVEQPEDMTGES
LIKH
3D structure
PDB4nwj Complete catalytic cycle of cofactor-independent phosphoglycerate mutase involves a spring-loaded mechanism
ChainA
Resolution2.01 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D12 S62 D154 R257 K330 D397 H401 D438 H439 H456
Catalytic site (residue number reindexed from 1) D11 S61 D153 R256 K329 D396 H400 D437 H438 H455
Enzyme Commision number 5.4.2.12: phosphoglycerate mutase (2,3-diphosphoglycerate-independent).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A D397 H401 H456 D396 H400 H455
BS02 MN A D12 S62 D438 H439 D11 S61 D437 H438
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004619 phosphoglycerate mutase activity
GO:0016853 isomerase activity
GO:0030145 manganese ion binding
GO:0046537 2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
GO:0046872 metal ion binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006007 glucose catabolic process
GO:0006096 glycolytic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Cellular Component
External links
PDB RCSB:4nwj, PDBe:4nwj, PDBj:4nwj
PDBsum4nwj
PubMed25611430
UniProtQ2G029

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