Structure of PDB 4nwc Chain A

Receptor sequence
>4nwcA (length=255) Species: 10116 (Rattus norvegicus) [Search protein sequence]
TNRSLIVTTLLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSY
EIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDF
SKPFMTLGVSILYRKGTPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKI
STFEKMWAFMSSKPSALVKNNEEGIQRTLTADYALLMESTTIEYITQRNC
NLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEKWWR
GSGCP
3D structure
PDB4nwc Molecular Recognition of Two 2,4-syn-Functionalized (S)-Glutamate Analogues by the Kainate Receptor GluK3 Ligand Binding Domain.
ChainA
Resolution2.012 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2QE A E443 Y491 P518 L519 T520 R525 G690 A691 T692 N722 E739 Y765 E12 Y60 P87 L88 T89 R94 G139 A140 T141 N171 E188 Y214 MOAD: Ki=1.74uM
PDBbind-CN: -logKd/Ki=5.76,Ki=1.74uM
BindingDB: Ki=1010nM
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:4nwc, PDBe:4nwc, PDBj:4nwc
PDBsum4nwc
PubMed25044437
UniProtP42264|GRIK3_RAT Glutamate receptor ionotropic, kainate 3 (Gene Name=Grik3)

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