Structure of PDB 4nw3 Chain A

Receptor sequence
>4nw3A (length=51) Species: 9606 (Homo sapiens) [Search protein sequence]
RRSRRCGQCPGCQVPEDCGVCTNCLDKPKFGGRNIKKQCCKMRKCQNLQW
M
3D structure
PDB4nw3 DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants.
ChainA
Resolution2.82 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.1.1.-
2.1.1.364: [histone H3]-lysine(4) N-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A S1152 R1154 K1186 Q1187 C1188 K1193 S3 R5 K37 Q38 C39 K44
BS02 dna A I1184 K1185 K1186 I35 K36 K37
BS03 ZN A C1167 C1170 C1173 C1189 C18 C21 C24 C40
BS04 ZN A C1155 C1158 C1161 C1194 C6 C9 C12 C45
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0008270 zinc ion binding

View graph for
Molecular Function
External links
PDB RCSB:4nw3, PDBe:4nw3, PDBj:4nw3
PDBsum4nw3
PubMed29276034
UniProtQ03164|KMT2A_HUMAN Histone-lysine N-methyltransferase 2A (Gene Name=KMT2A)

[Back to BioLiP]