Structure of PDB 4nvb Chain A

Receptor sequence

>4nvbA (length=289) Species: 285006 (Saccharomyces cerevisiae RM11-1a) [Search protein sequence]

LVHVASVEKGRSYEDFQKVYNAIALKLREDDEYDNYIGYGPVLVRLAWHI
SGTWDKHDNTGGSYGGTYRFKKEFNDPSNAGLQNGFKFLEPIHKEFPWIS
SGDLFSLGGVTAVQEMQGPKIPWRCGRVDTPEDTTPDNGRLPDADKDAGY
VRTFFQRLNMNDREVVALMGAHALGKTHLKNSGYEGGGANNVFTNEFYLN
LLNEDWKLEKNDANNEQWDSKSGYMMLPTDYSLIQDPKYLSIVKEYANDQ
DKFFKDFSKAFEKLLENGITFPKDAPSPFIFKTLEEQGL

3D structure

PDB

4nvb Incorporation of protein flexibility and conformational energy penalties in docking screens to improve ligand discovery.

Chain

Resolution

1.17 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	R48 H52 H175 D233
Catalytic site (residue number reindexed from 1)	R45 H49 H172 D230
Enzyme Commision number	1.11.1.- 1.11.1.5: cytochrome-c peroxidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	HEM	A	P44 R48 W51 P145 D146 A147 L171 M172 A174 H175 G178 K179 T180 H181 N184 S185 L230	P41 R45 W48 P142 D143 A144 L168 M169 A171 H172 G175 K176 T177 H178 N181 S182 L227
BS02	25T	A	H175 L177 G178 K179 T180 G190 M228	H172 L174 G175 K176 T177 G187 M225
BS03	25T	A	F89 L92 H96 S104	F86 L89 H93 S101

Gene Ontology

	Molecular Function
GO:0004601	peroxidase activity
GO:0020037	heme binding

	Biological Process
GO:0006979	response to oxidative stress
GO:0034599	cellular response to oxidative stress

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:4nvb, PDBe:4nvb, PDBj:4nvb
PDBsum	4nvb
PubMed	24950326
UniProt	B3LRE1

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