Structure of PDB 4nv0 Chain A

Receptor sequence
>4nv0A (length=299) Species: 7227 (Drosophila melanogaster) [Search protein sequence]
RLRLQDIPALTQDHCRMRDPAEVERIINEFVIGGPERMQIVSDFDYTITK
QRTEDGGAVPSSFGIFNACQSLPENFKAETDKLYHKYRPIEIDPHMPIAE
KVQYMIEWWTKSGELTSGFPFDQSEIDQIASKYTHALRDRTHEFFADLQR
LGIPTLVFSAGLGNSVVSVLRQANVLHPNVKVVSNFLQFRDGLLDGFQQP
MIHTFNKNETVLNETSEYYDLVHTRDHIIVMGDSIGDADMASGVPASSHI
MKIGFLFDHVEANMKKYMDTFDIVLVDDQTMDVPRTLLSLIEKQHKLNL
3D structure
PDB4nv0 Crystal Structures of the Novel Cytosolic 5'-Nucleotidase IIIB Explain Its Preference for m7GMP
ChainA
Resolution1.65 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.3.5: 5'-nucleotidase.
3.1.3.91: 7-methylguanosine nucleotidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A D55 D57 D245 D43 D45 D233
BS02 MG7 A F75 E103 W120 W121 S124 F63 E91 W108 W109 S112
BS03 MGF A D55 F56 D57 S171 A172 K219 D43 F44 D45 S159 A160 K207
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0008252 nucleotidase activity
GO:0008253 5'-nucleotidase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
GO:0106411 XMP 5'-nucleosidase activity
Biological Process
GO:0009117 nucleotide metabolic process
GO:0009158 ribonucleoside monophosphate catabolic process
GO:1901069 guanosine-containing compound catabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4nv0, PDBe:4nv0, PDBj:4nv0
PDBsum4nv0
PubMed24603684
UniProtQ9W197|5NT3B_DROME 7-methylguanosine phosphate-specific 5'-nucleotidase (Gene Name=cN-IIIB)

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