Structure of PDB 4nuy Chain A

Receptor sequence
>4nuyA (length=880) Species: 301447 (Streptococcus pyogenes serotype M1) [Search protein sequence]
PEKIPMKPLHGPLYGGYFRTWHDKTSDPTEKDKVNSMGELPKEVDLAFIF
HDWTKDYSLFWKELATKHVPKLNKQGTRVIRTIPWRFLAGGDNSGIAEDT
SKYPNTPEGNKALAKAIVDEYVYKYNLDGLDVDVEHDSIPKVDKKEDTAG
VERSIQVFEEIGKLIGPKGVDKSRLFIMDSTYMADKNPLIERGAPYINLL
LVQVYGSQGEKGGWEPVSNRPEKTMEERWQGYSKYIRPEQYMIGFSFYEE
NAQEGNLWYDINSRKDEDKANGINTDITGTRAERYARWQPKTGGVKGGIF
SYAIDRDGVAHQPKKYAKDATDNIFHSDYSVSKALKTVMLKDKSYDLIDE
KDFPDKALREAVMAQVGTRKGDLERFNGTLRLDNPAIQSLEGLNKFKKLA
QLDLIGLSRITKLDRSVLPANMKPGKDTLETVLETYKEEPATIPPVSLKV
SGLTGLKELDLSGFDRETLAGLDAATLTSLEKVDISGNKLDLAPGTENRQ
IFDTMLSTISNHVGSNEQTVKFDKQKPTGHYPDTYGKTSLRLPVANEKVD
LQSQLLFGTVTNQGTLINSEADYKAYQNHKIAGRSFVDSNYHYNNFKVSY
ENYTVKVTDSTLGTTTDKTLATDKEETYKVDFFSPADKTKAVHTAKVIVG
DEKTMMVNLAEGATVIGGSADPVNARKVFDGQLGSETDNISLGWDSKQSI
IFKLKEDGLIKHWRFFNDSARNPETTNKPIQEASLQIFNIKDYNLDNLLE
NPNKFDDEKYWITVDTYSAQGERATAFSNTLNNITSKYWRVVFDTKGDRY
SSPVVPELQILGYPLPNADTIMKTVTTAKELSQQKDKFSQKMLDELKIKE
MALETSLNSKIFDVTAINANAGVLKDCIEK
3D structure
PDB4nuy Crystal structure of Streptococcus pyogenes EndoS, an immunomodulatory endoglycosidase specific for human IgG antibodies.
ChainA
Resolution2.609 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.96: mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A K786 D789 Q791 P915 E916 K677 D680 Q682 P806 E807
Gene Ontology
Molecular Function
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0005509 calcium ion binding
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0033925 mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity
GO:0046872 metal ion binding
GO:0090729 toxin activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0042783 evasion of host immune response
Cellular Component
GO:0005576 extracellular region
GO:0043655 host extracellular space

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4nuy, PDBe:4nuy, PDBj:4nuy
PDBsum4nuy
PubMed24753590
UniProtQ99Y92|ENDOS_STRP1 Endo-beta-N-acetylglucosaminidase EndoS (Gene Name=endoS)

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