Structure of PDB 4nuc Chain A

Receptor sequence
>4nucA (length=126) Species: 9606 (Homo sapiens) [Search protein sequence]
SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVK
LNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNK
PGDDIVLMAEALEKLFLQKINELPTE
3D structure
PDB4nuc Structure-Guided Design of Potent Diazobenzene Inhibitors for the BET Bromodomains
ChainA
Resolution1.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 435 A W81 P82 V87 Y139 N140 I146 W40 P41 V46 Y98 N99 I105 MOAD: Ki=0.91uM
PDBbind-CN: -logKd/Ki=6.04,Ki=0.91uM
BindingDB: Ki=4300nM
External links
PDB RCSB:4nuc, PDBe:4nuc, PDBj:4nuc
PDBsum4nuc
PubMed24144283
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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