Structure of PDB 4ntj Chain A

Receptor sequence
>4ntjA (length=369) Species: 562,9606 [Search protein sequence]
LCTRDYKITQVLFPLLYTVLFFVGLITNGLAMRIFFQIRSKSNFIIFLKN
TVISDLLMILTFPFKILSDAKLLRTFVCQVTSVIFYFTMYISISFLGLIT
IDRYQKTTRPFKTKNLLGAKILSVVIWAFMFLLSLPNMILKSEFGLVWHE
IVNYICQVIFWINFLIVIVCYTLITKELYRSYVRTADLEDNWETLNDNLK
VIEKADNAAQVKDALTKMRAAALDAQKATPPKLEDFRHGFDILVGQIDDA
LKLANEGKVKEAQAAAEQLKTTRNAYIQKYLRGVGKVRKKVNVKVFIIIA
VFFICFVPFHFARIPYTLSQTRDVFDCTAENTLFYVKESTLWLTSLNACL
NPFIYFFLCKSFRNSLISM
3D structure
PDB4ntj Structure of the human P2Y12 receptor in complex with an antithrombotic drug
ChainA
Resolution2.62 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AZJ A V102 Y105 F106 Y109 S156 N159 V190 N191 C194 R256 Y259 K280 V83 Y86 F87 Y90 S134 N137 V152 N153 C156 R313 Y316 K337 PDBbind-CN: -logKd/Ki=7.36,Ki=43.9nM
BS02 CLR A I23 L27 S282 W285 I8 L12 S339 W342
BS03 CLR A I120 I200 V207 I101 I162 V169
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0005506 iron ion binding
GO:0009055 electron transfer activity
GO:0020037 heme binding
GO:0045028 G protein-coupled purinergic nucleotide receptor activity
GO:0046872 metal ion binding
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007194 negative regulation of adenylate cyclase activity
GO:0007596 blood coagulation
GO:0022900 electron transport chain
Cellular Component
GO:0016020 membrane
GO:0042597 periplasmic space

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Cellular Component
External links
PDB RCSB:4ntj, PDBe:4ntj, PDBj:4ntj
PDBsum4ntj
PubMed24670650
UniProtP0ABE7|C562_ECOLX Soluble cytochrome b562 (Gene Name=cybC);
Q9H244|P2Y12_HUMAN P2Y purinoceptor 12 (Gene Name=P2RY12)

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