Structure of PDB 4ntb Chain A

Receptor sequence
>4ntbA (length=146) Species: 10090 (Mus musculus) [Search protein sequence]
HHKDEVALLATVTLVGVLLQAYFSLQVISARRAFHVSPPLTSGPPEFERV
FRAQVNCSEYFPLFLATLWVAGIFFHEGAAALCGLFYLFARLRYFQGYAR
SAQLRLTPLYASARALWLLVAMAALGLLVHFLPGTLRTALFRWLQM
3D structure
PDB4ntb Mus Musculus LTC4 synthase in GSH complex form
ChainA
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.-
4.4.1.20: leukotriene-C4 synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GSH A R51 N55 E58 Y59 Y97 R104 L108 R52 N56 E59 Y60 Y98 R105 L109
Gene Ontology
Molecular Function
GO:0004464 leukotriene-C4 synthase activity
GO:0008047 enzyme activator activity
GO:0008289 lipid binding
GO:0016740 transferase activity
GO:0016829 lyase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0006691 leukotriene metabolic process
GO:0019370 leukotriene biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005640 nuclear outer membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0031965 nuclear membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4ntb, PDBe:4ntb, PDBj:4ntb
PDBsum4ntb
PubMed
UniProtQ60860|LTC4S_MOUSE Leukotriene C4 synthase (Gene Name=Ltc4s)

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