Structure of PDB 4nt0 Chain A

Receptor sequence
>4nt0A (length=213) Species: 145262 (Methanothermobacter thermautotrophicus) [Search protein sequence]
RSRRVDVMDVMNRLILAMDLMNRDDALRVTGEVREYIDTVKIGYPLVLSE
GMDIIAEFRKRFGCRIIADFKVADIPETNEKICRATFKAGADAIIVHGFP
GADSVRACLNVAEEMGREVFLLTEMSHPGAEMFIQGAADEIARMGVDLGV
KNYVGPSTRPERLSRLREIIGQDSFLISPGETLRFADAIIVGRSIYLADN
PAAAAAGIIESIK
3D structure
PDB4nt0 Crystal structure of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with 3-deazauridine 5'-monophosphate
ChainA
Resolution1.769 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) K42 D70 K72 D75
Catalytic site (residue number reindexed from 1) K41 D69 K71 D74
Enzyme Commision number 4.1.1.23: orotidine-5'-phosphate decarboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3DU A D20 K72 M126 S127 P180 G202 R203 D19 K71 M125 S126 P179 G192 R193
BS02 CA A R5 V6 V8 M9 D10 R4 V5 V7 M8 D9
Gene Ontology
Molecular Function
GO:0004590 orotidine-5'-phosphate decarboxylase activity
GO:0016831 carboxy-lyase activity
Biological Process
GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
GO:0006221 pyrimidine nucleotide biosynthetic process
GO:0044205 'de novo' UMP biosynthetic process
Cellular Component
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4nt0, PDBe:4nt0, PDBj:4nt0
PDBsum4nt0
PubMed
UniProtO26232|PYRF_METTH Orotidine 5'-phosphate decarboxylase (Gene Name=pyrF)

[Back to BioLiP]