Structure of PDB 4nst Chain A

Receptor sequence
>4nstA (length=323) Species: 9606 (Homo sapiens) [Search protein sequence]
ESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKE
GFPITAIREIKILRQLIHRSVVNMKEIVTDKQDGAFYLVFEYMDHDLMGL
LESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQI
KLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCG
CILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMK
PKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDV
ELSKMAPPDLPHWQDCHELWSKK
3D structure
PDB4nst The structure and substrate specificity of human Cdk12/Cyclin K.
ChainA
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D859 K861 S863 N864 D877 S889 T898
Catalytic site (residue number reindexed from 1) D136 K138 S140 N141 D154 S166 T175
Enzyme Commision number 2.7.11.22: cyclin-dependent kinase.
2.7.11.23: [RNA-polymerase]-subunit kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A G736 T737 A754 K756 Y815 M816 D819 S863 L866 D877 H1040 G21 T22 A39 K41 Y92 M93 D96 S140 L143 D154 H317
BS02 AF3 A D859 K861 N864 D877 D136 K138 N141 D154
BS03 MG A N864 D877 N141 D154
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4nst, PDBe:4nst, PDBj:4nst
PDBsum4nst
PubMed24662513
UniProtQ9NYV4|CDK12_HUMAN Cyclin-dependent kinase 12 (Gene Name=CDK12)

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