Structure of PDB 4nrq Chain A

Receptor sequence
>4nrqA (length=210) Species: 9606 (Homo sapiens) [Search protein sequence]
EQQLQKEEEARKVKSGIRQMRLFSQDECAKIEARIDEVVSRAEKGLYNEH
TVDRAPLRNKYFFGEGYTGQERLYPPGDVDEIPEWVHQLVIQKLVEHRVI
PEGFVNSAVINDYQPGGCIVSHVDPIHIFERPIVSVSFFSDSALCFGCKF
QFKPIRVSEPVLSLPVRRGSVTVLSGYAADEITHCIRPQDIKERRAVIIL
RKTRLDAPRL
3D structure
PDB4nrq Crystal structures of the human RNA demethylase Alkbh5 reveal basis for substrate recognition
ChainA
Resolution2.5 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 1.14.11.53: mRNA N(6)-methyladenine demethylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PD2 A N193 Y195 I201 H204 L226 H266 I268 R277 V279 I281 N111 Y113 I119 H122 L144 H184 I186 R195 V197 I199 PDBbind-CN: -logKd/Ki=3.46,IC50=347.2uM
BS02 MN A H204 D206 H266 H122 D124 H184
Gene Ontology
Molecular Function
GO:0035515 oxidative RNA demethylase activity
Biological Process
GO:0006397 mRNA processing

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4nrq, PDBe:4nrq, PDBj:4nrq
PDBsum4nrq
PubMed24616105
UniProtQ6P6C2|ALKB5_HUMAN RNA demethylase ALKBH5 (Gene Name=ALKBH5)

[Back to BioLiP]