Structure of PDB 4nrp Chain A

Receptor sequence
>4nrpA (length=211) Species: 9606 (Homo sapiens) [Search protein sequence]
QQLQKEEEARKVKSGIRQMRLFSQDECAKIEARIDEVVSRAEKGLYNEHT
VDRAPLRNKYFFGEGYTGPGQERLYPPGDVDEIPEWVHQLVIQKLVEHRV
IPEGFVNSAVINDYQPGGCIVSHVDPIHIFERPIVSVSFFSDSALCFGCK
FQFKPIRVSEPVLSLPVRRGSVTVLSGYAADEITHCIRPQDIKERRAVII
LRKTRLDAPRL
3D structure
PDB4nrp Crystal structures of the human RNA demethylase Alkbh5 reveal basis for substrate recognition
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.53: mRNA N(6)-methyladenine demethylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A H204 D206 H266 H123 D125 H185
Gene Ontology
Molecular Function
GO:0035515 oxidative RNA demethylase activity
Biological Process
GO:0006397 mRNA processing

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Molecular Function
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Biological Process
External links
PDB RCSB:4nrp, PDBe:4nrp, PDBj:4nrp
PDBsum4nrp
PubMed24616105
UniProtQ6P6C2|ALKB5_HUMAN RNA demethylase ALKBH5 (Gene Name=ALKBH5)

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