Structure of PDB 4nro Chain A

Receptor sequence
>4nroA (length=213) Species: 9606 (Homo sapiens) [Search protein sequence]
EQQLQKEEEARKVKSGIRQMRLFSQDECAKIEARIDEVVSRAEKGLYNEH
TVDRAPLRNKYFFGEGYTYGPGQERLYPPGDVDEIPEWVHQLVIQKLVEH
RVIPEGFVNSAVINDYQPGGCIVSHVDPIHIFERPIVSVSFFSDSALCFG
CKFQFKPIRVSEPVLSLPVRRGSVTVLSGYAADEITHCIRPQDIKERRAV
IILRKTRLDAPRL
3D structure
PDB4nro Crystal structures of the human RNA demethylase Alkbh5 reveal basis for substrate recognition
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.53: mRNA N(6)-methyladenine demethylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A H204 D206 H266 H125 D127 H187
BS02 AKG A N193 I201 H204 H266 I268 R277 I281 N114 I122 H125 H187 I189 R198 I202 PDBbind-CN: -logKd/Ki=5.02,Kd~9.6uM
Gene Ontology
Molecular Function
GO:0035515 oxidative RNA demethylase activity
Biological Process
GO:0006397 mRNA processing

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Molecular Function
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Biological Process
External links
PDB RCSB:4nro, PDBe:4nro, PDBj:4nro
PDBsum4nro
PubMed24616105
UniProtQ6P6C2|ALKB5_HUMAN RNA demethylase ALKBH5 (Gene Name=ALKBH5)

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