Structure of PDB 4nrc Chain A

Receptor sequence
>4nrcA (length=115) Species: 9606 (Homo sapiens) [Search protein sequence]
SMSVKKPKRDDSKDLALCSMILTEMETHEDAWPFLLPVNLKLVPGYKKVI
KKPMDFSTIREKLSSGQYPNLETFALDVRLVFDNCETFNEDDSDIGRAGH
NMRKYFEKKWTDTFK
3D structure
PDB4nrc Targeting low-druggability bromodomains: fragment based screening and inhibitor design against the BAZ2B bromodomain.
ChainA
Resolution1.86 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2LY A P1888 F1889 P33 F34 MOAD: ic50=241uM
PDBbind-CN: -logKd/Ki=3.62,IC50=241uM
BindingDB: IC50=241000nM
External links
PDB RCSB:4nrc, PDBe:4nrc, PDBj:4nrc
PDBsum4nrc
PubMed24304323
UniProtQ9UIF8|BAZ2B_HUMAN Bromodomain adjacent to zinc finger domain protein 2B (Gene Name=BAZ2B)

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