Structure of PDB 4nrb Chain A

Receptor sequence
>4nrbA (length=114) Species: 9606 (Homo sapiens) [Search protein sequence]
SMSVKKPKRDDSKDLALCSMILTEMETHEDAWPFLLPVNLKLVPGYKKVI
KKPMDFSTIREKLSSGQYPNLETFALDVRLVFDNCETFNEDDSDIGRAGH
NMRKYFEKKWTDTF
3D structure
PDB4nrb Targeting low-druggability bromodomains: fragment based screening and inhibitor design against the BAZ2B bromodomain.
ChainA
Resolution2.08 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2LX A P1888 F1889 V1893 V1898 F1943 N1944 I1950 P33 F34 V38 V43 F88 N89 I95 MOAD: ic50=38uM
PDBbind-CN: -logKd/Ki=4.42,IC50=38uM
BindingDB: IC50=38000nM
External links
PDB RCSB:4nrb, PDBe:4nrb, PDBj:4nrb
PDBsum4nrb
PubMed24304323
UniProtQ9UIF8|BAZ2B_HUMAN Bromodomain adjacent to zinc finger domain protein 2B (Gene Name=BAZ2B)

[Back to BioLiP]